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Publications and posters

Recommended

Explore some of our latest publications showcasing the discoveries enabled by the Aiforia® Platform

Publication

Digital pathology structure and deployment in Veneto: a proof-of-concept study

Eccher A, Marletta S, Sbaraglia M, et al.

Virchows Archiv
2024
Publication

Democratizing Artificial Intelligence in Anatomic Pathology

Flotte TJ, Derauf SA, Byrd RK, et al.

Archives of Pathology & Laboratory Medicine
2024

All publications

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Poster

A threefold evaluation of HER2low status of advanced breast carcinomas in core biopsies, matching surgical specimens and their distant metastases. A retrospective study of 47 patients using conventional microscopy, digital pathology and artificial intelligence (AI)

Kovács A, Klint L, Janeva S, et al.

Sahlgrenska University Hospital
2024
Publication

Heterozygous loss of Engrailed-1 and α-synucleinopathy (En1/SYN): A dual-hit preclinical mouse model of Parkinson’s disease, analyzed with artificial intelligence

Stetzik L, Mercado G, Steiner JA, et al.

Neurobiology of Disease
2024
Publication

Artificial intelligence-based quantification of lymphocytes in feline small intestinal biopsies

Wulcan JM, Giaretta PR, Fingerhood S, et al.

Vet Pathol.
2024
Publication

Galileo—an Artificial Intelligence tool for evaluating pre-implantation kidney biopsies

Eccher A, L’Imperio V, Pantanowitz L, et al.

Journal of Nephrology
2024
Publication

Advancements and applications of AI technologies in pathology: a scoping review

Salo I, Nordlund L, Eklund L, et al.

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization
2024
Publication

Deep learning model shows pathologist-level detection of sentinel node metastasis of melanoma and intra-nodal nevi on whole slide images

Siarov J, Siarov A, Kumar D, et al.

Frontiers in Medicine
2024
Publication

CD163+ macrophages in mantle cell lymphoma induce activation of pro-survival pathways and immune suppression

Rodrigues JM, Lokhande L, Olsson LM, et al.

Blood Advances
2024
Publication

Deep learning assisted quantitative analysis of Aβ and microglia in patients with idiopathic normal pressure hydrocephalus in relation to cognitive outcome

Luikku AJ, Nerg O, Koivisto AM, et al.

Journal of Neuropathology & Experimental Neurology
2024
Publication

Utilizing deep learning model for assessing melanocytic density in resection margins of lentigo maligna

Siarov J, Kumar D, Paoli J, et al.

Journal of Neuropathology & Experimental Neurology
2024
Publication

B cells in perivascular and peribronchiolar granuloma-associated lymphoid tissue and B-cell signatures identify asymptomatic Mycobacterium tuberculosis lung infection in Diversity Outbred mice

Koyuncu D, Tavolara T, Gatti DM, et al.

Infection and Immunity
2024
Publication

Limbic-predominant age-related TDP-43 encephalopathy in the oldest old: a population-based study

Mikhailenko E, Colangelo K, Tuimala J, et al.

Brain
2024
Publication

A deep-learning-based model for assessment of autoimmune hepatitis from histology: AI(H)

Ercan C, Kordy K, Knuuttila A, et al.

Virchows Archiv
2024
Poster

175P-Utility of artificial intelligence (AI) in Ki-67 scoring of a breast cancer (BC) patientpopulation

Pichon X, Gaspo R, Kumar D, et al.

Cerba Research
2024
Publication

Digital pathology structure and deployment in Veneto: a proof-of-concept study

Eccher A, Marletta S, Sbaraglia M, et al.

Virchows Archiv
2024
Publication

Consistent and effective method to define the mouse estrous cycle stage by a deep learning-based model

Strauss L, A Junnila A, Wärri A, et al.

Journal of Endocrinology
2024
Publication

Improved risk stratification scheme for mismatch repair proficient stage II colorectal cancers using the digital pathology biomarker QuantCRC

Wu C, Pai RK, Kosiorek H, et al.

Clinical Cancer Research
2024
Poster

Artificial Intelligence-based Histopathological Analysis Identifies Unique Correlates of Tuberculosis

Stetzik L, Westerling-Bui T, Sihvo HK, et al.

Aiforia Technologies Plc
2024
Publication

Democratizing Artificial Intelligence in Anatomic Pathology

Flotte TJ, Derauf SA, Byrd RK, et al.

Archives of Pathology & Laboratory Medicine
2024
Publication

Diagnosis of soil-transmitted helminth infections with digital mobile microscopy and artificial intelligence in a resource-limited setting

Lundin J, Suutala A, Holmström O, et al.

PLOS Neglected Tropical Diseases
2024
Publication

Opening the Black Box: Spatial Transcriptomics and the Relevance of Artificial Intelligence–Detected Prognostic Regions in High-Grade Serous Carcinoma

Laury AR, Zhenga S, Ahoa N, et al.

Modern Pathology
2024
Publication

MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 - a Nordic Lymphoma Group study

Rodrigues JM, Hollander P, Schmidt L, et al.

Haematologica
2024
Poster

Automated Assessment of Ki-67 Proliferation Index of Canine Mast Tumours Using Computational Deep Learning

Fox R, Dobromylskyj M, Ide A, et al.

Aiforia Technologies Plc
2024
Publication

Development and characterization of a non-human primate model of disseminated synucleinopathy

Rico AJ, Corcho A, Chocarro J, et al.

Frontiers in Neuroanatomy
2024
Publication

Prediction of Tuberculosis From Lung Tissue Images of Diversity Outbred Mice Using Jump Knowledge Based Cell Graph Neural Network

Acharya V, Choi D, Yener B, et al.

IEEE Access
2024
Poster

Automated Assessment of Necrotic Neurons and Dark Artifactual Neurons in Transgenic Mouse Model of Alzheimer’s Disease Using Deep Learning

Youssef SA, Rekinen S, Fox R, et al.

Global Pathobiology
2024
Publication

Manually pressurized droplet digital PCR chip for rapid SARS-CoV-2 diagnostics

Elomaa P, Ojalehto T, Kumar D, et al.

Biomicrofluidics
2024
Poster

Assessment of Compound-Induced Hepatocellular Hypertrophy in Rats Through Deep Learning-based Quantitative Analysis

Fox R, Väisänen T, Rekinen S, et al.

Aiforia Technologies Plc
2024
Publication

External validation of a deep learning-based algorithm for detection of tall cells in papillary thyroid carcinoma: A multicenter study

Stenman S, Bétrisey S, Vainio P, et al.

J Pathol Inform
2024
Poster

Aiforia Clinical Suite for Prostate Cancer: A Holistic AssistiveTool for Prostate Cancer Diagnostics

Karjalainen M, Tumiati M, Wester A, et al.

University of Helsinki
2024
Publication

Deep learning quantification reveals a fundamental prognostic role for ductular reaction in biliary atresia

Nyholm I, Sjöblom N, Pihlajoki M, et al.

Hepatology Communications
2023
Publication

Neuromelanin accumulation drives endogenous synucleinopathy in non-human primates

Chocarro J, Rico AJ, Ariznabarreta G, et al.

Brain
2023
Publication

Ixodes scapularis nymph saliva protein blocks host inflammation and complement-mediated killing of Lyme disease agent, Borrelia burgdorferi

Bencosme-Cuevas E, Kim TK, Nguyen TT, et al.

Front. Cell. Infect. Microbiol.
2023
Publication

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

Westcott PMK, Muyas F, Hauck H, et al.

Nat Genet.
2023
Publication

Deep learning based image analysis of liver steatosis in mouse models

Mairinoja L, Heikelä H, Blom S, et al.

The American Journal of Pathology
2023
Publication

Performance of an Artificial Intelligence Model for Recognition and Quantitation of Histologic Features of Eosinophilic Esophagitis on Biopsy Samples

Archila LR, Smith L, Sihvo HK, et al.

Modern Pathology
2023
Publication

Comparative Evaluation of Breast Ductal Carcinoma Grading: A Deep-Learning Model and General Pathologists’ Assessment Approach

Köteles MM, Vigdorovits A, Kumar D, et al.

Diagnostics
2023
Publication

Core Needle Biopsy Guidance Based on Tissue Morphology Assessment with AI-OCT Imaging

Maguluri G, Grimble J, Caron A, et al.

Diagnostics
2023
Publication

Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling

Avallone M, Pardo J, Mergiya TF, et al.

Frontiers in Molecular Neuroscience
2023
Poster

Evidence for the utility of artificial intelligence (AI) and image analysis in Ki-67 quantification in solid tumors

Pichon X, Gaspo R, Iglesias S, et al.

Cerba Research
2023
Poster

Clinical Validation and Implementation of an Artificial Intelligence Model for Digital Analysis of Ki-67 Biomarker in Breast Cancer

Rosario K, Stoy L, Blom S, et al.

Mayo Clinic
2023
Publication

Beneficial behavioral effects of chronic cerebral dopamine neurotrophic factor (CDNF) infusion in the N171-82Q transgenic model of Huntington’s disease

Stepanova P, Kumar D, Cavonius K, et al.

Scientific Reports
2023
Poster

Artificial Intelligence-Aided Diagnostics Saves Time and Improves Reliability of PD-L1 Scoring in Non-Small Cell Lung Cancer

Sjöblom N, Laury A, Kovala M, et al.

Aiforia Technologies Plc
2023
Publication

Development and evaluation of deep learning algorithms for assessment of acute burns and the need for surgery

Boissin c, Laflamme L, Lundin M, et al.

Scientific Reports
2023
Poster

Diagnosis 2.0 AI-Assisted Gleason Group Grading in Prostate Cancer

Karjalainen M, Neittaanmäki N, Puttonen H, et al.

Aiforia Technologies Plc
2023
Publication

High relative amount of nodular calcification in femoral plaques is associated with milder lower extremity arterial disease

Azeez M, Laivuori M, Tolva J et al.

BMC Cardiovascular Disorders
2022
Publication

Quantitative pathologic analysis of digitized images of colorectal carcinoma improves prediction of recurrence free survival

Pai RK, Banerjee I, Shivji S, et al.

Gastroenterology
2022
Publication

Development and Technical Validation of an Artificial Intelligence Model for Quantitative Analysis of Histopathologic Features of Eosinophilic Esophagitis

Archila LR, Smith L, Sihvo HK, et al.

Journal of Pathology Informatics
2022
Publication

Deep Learning-Based Segmentation of Morphologically Distinct Rat Hippocampal Reactive Astrocytes After Trimethyltin Exposure

Vuorimaa M, Kareinen I, Toivanen P, et al.

Toxicologic Pathology
2022
Publication

A novel automated morphological analysis of Iba1+ microglia using a deep learning assisted model

Stetzik L, Mercado G, Smith L, et al.

Frontiers in Cellular Neuroscience
2022
Publication

Automated Image Analysis of Keratin 7 Staining Can Predict Disease Outcome in Primary Sclerosing Cholangitis

Sjöblom N, Boyd S, Manninen A, et al.

Hepathology Research
2022
Publication

A deep learning–based algorithm for tall cell detection in papillary thyroid carcinoma

Stenman S, Linder N, Lundin M et al.

PLoS ONE
2022
Publication

Changes in glial cell phenotypes precede overt neurofibrillary tangle formation, correlate with markers of cortical cell damage, and predict cognitive status of individuals at Braak III-IV stages

Taddei RN, Sanchez-Mico MV, Bonnar O, et al.

Acta Neuropathologica Communications
2022
Publication

AI Model for Prostate Biopsies Predicts Cancer Survival

Sandeman K, Blom S, Koponen V, et al.

Diagnostics
2022
Publication

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration

Hastings L, Sokratian A, Apicco DJ, et al.

Brain Communications
2022
Poster

Additional Validation of a Deep Learning Algorithm to Quantify Histologic Features in Colorectal Carcinoma

Shivji S, Pai R, Rosty C, et al.

Mayo Clinic
2022
Publication

Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease

Kim C, Haldiman T, Kang SG, et al.

Science Translational Medicine
2022
Publication

Automated assessment of Ki-67 proliferation index in neuroendocrine tumors by deep learning

Vesterinen T, Säilä J, Blom S, et al.

APMIS.
2022
Poster

Development of an Artificial Intelligence Model for the Evaluation of Histopathologic Features of Eosinophilic Esophagitis

Archila LR, O’Sullivan D, Cardenas-Fernandez MC, et al.

Mayo Clinic
2022
Publication

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids

Fagerlund I, Dougalis A, Shakirzyanova A, et al.

Cells
2021
Publication

Development and validation of a supervised deep learning algorithm for automated whole-slide programmed death-ligand 1 tumour proportion score assessment in non-small cell lung cancer

Hondelink LM, Hüyük M, Postmus PE, et al.

Histopathology
2021
Publication

Monitoring of a progressive functional dopaminergic deficit in the A53T-AAV synuclein rats by combining 6-[18F]fluoro-L-m-tyrosine imaging and motor performances analysis

Becker G, Michel A, Bahri MA, et al.

Neurobiology of Aging
2021
Publication

MicroRNA-7 Protects Against Neurodegeneration Induced by α-Synuclein Preformed Fibrils in the Mouse Brain

Zhang J, Zhao M, Yan R, et al.

Neurotherapeutics
2021
Publication

Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer

Westcott PMK, Sacks NJ, Schenkel JM, et al.

Nature Cancer
2021
Publication

Artificial intelligence-based image analysis can predict outcome in high-grade serous carcinoma via histology alone

Laury AR, Blom S, Ropponen T, et al.

Scientific Reports
2021
Publication

Differential impact of clinicopathological risk factors within the 2 largest ProMisE molecular subgroups of endometrial carcinoma

Pasanen A, Loukovaara M, Ahvenainen T, et al.

PLoS ONE
2021
Publication

Parvalbumin subtypes of cerebellar Purkinje cells contribute to differential intrinsic firing properties

Brandenburg C, Smith LA, Kilander MBC, et al.

Molecular and Cellular Neuroscience
2021
Publication

Deep learning assisted quantitative assessment of histopathological markers of Alzheimer’s disease and cerebral amyloid angiopathy

Perosa V, Scherlek AA, Kozberg MG, et al.

Acta Neuropathologica Communications
2021
Publication

Functional diagnostics using fresh uncultured lung tumor cells to guide personalized treatments

Talwelkar SS, Mäyränpää MI, Søraas L, et al.

Cell Reports Medicine
2021
Publication

Hantavirus infection-induced B cell activation elevates free light chains levels in circulation

Hepojoki J, Cabrera LE, Hepojoki S, et al

PLoS Pathogens
2021
Publication

Neuroprotective Potential of a Small Molecule RET Agonist in Cultured Dopamine Neurons and Hemiparkinsonian Rats

Renko JM, Mahato AK, Visnapuu T, et al.

Journal of Parkinson's Disease
2021
Publication

Utilizing Deep Learning to Analyze Whole Slide Images of Colonic Biopsies for Associations Between Eosinophil Density and Clinicopathologic Features in Active Ulcerative Colitis

Vande Casteele N, Leighton JA, Pasha SF, et al.

Inflammatory Bowel Diseases
2021
Publication

Developing a Qualification and Verification Strategy for Digital Tissue Image Analysis in Toxicological Pathology

Zuraw A, Staup M, Klopfleisch R, et al.

Toxicologic Pathology
2021
Publication

Chronic cholestasis detection by a novel tool: automated analysis of cytokeratin 7-stained liver specimens

Sjöblom N, Boyd S, Manninen A, et al.

Diagnostic Pathology
2021
Publication

High tumor cell platelet-derived growth factor receptor beta expression is associated with shorter survival in malignant pleural epithelioid mesothelioma

Ollila H, Paajanen J, Wolff H, et al.

The Journal of Pathology
2021
Publication

Glucocerebrosidase Gene Therapy Induces Alpha-Synuclein Clearance and Neuroprotection of Midbrain Dopaminergic Neurons in Mice and Macaques

Sucunza D, Rico AJ, Roda E, et al.

International Journal of Molecular Sciences
2021
Publication

Point-of-Care Digital Cytology With Artificial Intelligence for Cervical Cancer Screening in a Resource-Limited Setting

Holmström O, Linder N, Kaingu H, et al.

Jama Network Open
2021
Publication

Monocyte subset redistribution from blood to kidneys in patients with Puumala virus caused hemorrhagic fever with renal syndrome

Vangeti S, Strandin T, Liu S, et al.

PLoS Pathogens
2021
Publication

Development and initial validation of a deep learning algorithm to quantify histologic features in colorectal carcinoma including tumour budding/poorly differentiated clusters

Pai RK, Hartman S, Schaeffer DF, et al.

Histopathology
2021
Publication

Deep neural network analysis - a paradigm shift for histological examination of health and welfare of farmed fish

Sveen L, Timmerhaus G, Johansen LH, Ytteborg E, et al.

Aquaculture
2021
Publication

Proof of Concept for a Deep Learning Algorithm for Identification and Quantification of Key Microscopic Features in the Murine Model of DSS-Induced Colitis

Bédard A, Westerling-Bui T, Zuraw A, et al.

Toxicologic Pathology
2021
Publication

Screening For Bone Marrow Cellularity Changes in Cynomolgus Macaques in Toxicology Safety Studies Using Artificial Intelligence Models

Smith MA, Westerling-Bui T, Wilcox A, et al.

Toxicologic Pathology
2021
Publication

Artificial intelligence identifies inflammation and confirms fibroblast foci as prognostic tissue biomarkers in idiopathic pulmonary fibrosis

Mäkelä K, Mäyränpää M, Sihvo HK, et al.

Human Pathology
2021
Poster

AI(H): Deep Learning Model for Staging and Grading Autoimmune Hepatitis from Histology

Ercan C, Kordy K, Knuuttila A, et al.

Novartis and University of Basel
2021
Publication

Machine-learning–driven biomarker discovery for the discrimination between allergic and irritant contact dermatitis

Fortino V, Wisgrill L, Werner P, et al.

PNAS
2020
Publication

Osteoid metaplasia in femoral artery plaques is associated with the clinical severity of lower extremity artery disease in men

Laivuori M, Tolva J, Lokki AI, et al.

Frontiers in Cardiovascular Medicine
2020
Publication

A novel deep learning-based point-of-care diagnostic method for detecting Plasmodium falciparum with fluorescence digital microscopy

Holmström O, Stenman S, Suutala A, et al.

PLoS ONE
2020
Publication

Quantitative neurotoxicology: Potential role of artificial intelligence/deep learning approach

Srivastava A. & Hanig JP.

Journal of Applied Toxicology
2020
Publication

Evaluating the optimum number of biopsies to assess histological inflammation in ulcerative colitis: a retrospective cohort study

Battat R, Casteele NV, Pai RK, et al.

Alimentary Pharmacology and Therapeutics
2020
Publication

Fetal HLA-G mediated immune tolerance and interferon response in preeclampsia

Wedenoja S, Yoshihara M, Teder H, et al.

EBioMedicine
2020
Publication

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

Charidimou A, Perosa V, Frosch MP, et al.

Brain
2020
Publication

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

Romero R, Sánchez-Rivera FJ, Westcott PMK, et al.

Nature Cancer
2020
Publication

Using online game-based platforms to improve student performance and engagement in histology teaching

Felszeghy S, Pasonen-Seppänen S, Koskela A, et al.

BMC Medical Education
2019
Publication

Breast cancer outcome prediction with tumour tissue images and machine learning

Turkki R, Byckhov D, Lundin M, et al.

Breast Cancer Research and Treatment
2019
Poster

Artificial Intelligence Enables Efficient and Reproducible Quantitative Rodent Toxicology Ovarian Follicle Evaluation

Rudmann DG, Swanson C, Tarkiainen K, et al.

Charles River Laboratories
2019
Publication

Detection of breast cancer lymph nodemetastases in frozen sections with a point-ofcare low-cost microscope scanner

Holmström O, Linder N, Moilanen H, et al.

PLOS One
2019
Poster

A Deep Learning Algorithm to Quantify Liver Fat Content in Humans

Qadri S, Ahtiainen L, Boyd S, et al.

University of Helsinki
2019
Poster

Systemically administered Aflibercept protects against the development of neovascular lesions in the mouse laser-induced choroidal neovascularization model

Vähätupa M, Ragauskas S, Žiniauskaite A, et al.

Experimentica
2019
Poster

Using deep neural networks to count Ki-67 positive cells in neuroendocrine tumors

Mola N & Leh S

Haukeland University Hospital
2019
Publication

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours

Linder N, Taylor JC, Colling R, et al.

Journal of Clinical Pathology
2018
Publication

Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB

Yan R, Zhang J, Park H, et al.

PNAS
2018
Publication

PTEN Loss but Not ERG Expression in Diagnostic Biopsies Is Associated with Increased Risk of Progression and Adverse Surgical Findings in Men with Prostate Cancer on Active Surveillance

Lokman U, Erickson AM, Vasarainen H, et al.

European Urology Focus
2018
Publication

Downregulation of tyrosine hydroxylase phenotype after AAV injection above substantia nigra: Caution in experimental models of Parkinson’s disease

Albert K, Voutilainen MH, Domanskyi A, et al.

Journal of Neuroscience Research
2018
Publication

Implementation of deep neural networks to count dopamine neurons in substantia nigra

Penttinen A, Parkkinen I, Blom S, et al.

EJN
2018
Publication

The prognostic significance of tall cells in papillary thyroid carcinoma: A case-control study

Stenman S, Siironen P, Mustonen H, et al.

Tumor Biology
2018
Publication

Reliability of histologic assessment in patients with eosinophilic oesophagitis

Warners MJ, Ambarus CA, Bredenoord AJ, et al.

AP&T
2018
Poster

Deep convolutional neural network-based method for quantification of the pancreatic β-cell mass in mice

Danilova T, Blom S, Ropponen T, et al.

University of Helsinki
2018
Poster

Implementation of Neural Networks for studies of brain pathology in Parkinson´s disease

Parkkinen I, Penttinen AM, Kopra J, et al.

University of Helsinki
2018
Poster

Deep-learning neural network in prostate cancer detection and grading

Sandeman K, Blom S, Ropponen R, et al.

University of Helsinki
2018
Poster

A deep-learning algorithm to determine liver fat content in non-alcoholic fatty liver disease in humans

Ahtiainen LE, Luukkonen PK, Ropponen T, et al.

University of Helsinki
2018
Publication

Student-focused virtual histology education: Do new scenarios and digital technology matter?

Felszeghy S, Pasonen-Seppänen S, Koskela A, et al.

Med Ed Publish
2017
Publication

Point-of-care mobile digital microscopy and deep learning for the detection of soil-transmitted helminths and Schistosoma haematobium

Holmström O, Linder N, Ngasala B, et al.

Global Health Action
2017
Publication

Antibody-supervised deep learning for quantification of tumor-infiltrating immune cells in hematoxylin and eosin stained breast cancer samples

Turkki R, Linder N, Kovanen PE, et al.

Journal of Pathology Informatics
2016
Publication

Quantification of Estrogen Receptor-Alpha Expression in Human Breast Carcinomas With a Miniaturized, Low-Cost Digital Microscope: A Comparison with a High-End Whole Slide-Scanner

Holmström O, Linder N, Lundin M, et al.

PLOS One
2015
Publication

Exploring viewing behavior data from whole slide images to predict correctness of students’ answers during practical exams in oral pathology

Walkowski S, Lundin M, Szymas J, et al.

Journal of Pathology Informatics
2015
Publication

Assessment of tumour viability in human lung cancer xenografts with texture-based image analysis

Turkki R, Linder N, Holopainen T, et al.

Journal of Clinical Pathology
2015
Publication

Students' performance during practical examination on whole slide images using view path tracking

Walkowski S, Lundin M, Szymas J, et al.

Diagnostic Pathology
2014
Publication

A Malaria Diagnostic Tool Based on Computer Vision Screening and Visualization of Plasmodium falciparum Candidate Areas in Digitized Blood Smears

Linder N, Turkki R, Walliander M, et al.

PLOS One
2014